YANTAI, CHINA - Media OutReach - 28 March 2023 - Boan Biotech (6955.HK) announced its 2022 financial results and recent business developments on March 27, 2023. 2022 business highlights

• Record high in revenue: In 2022, Boan Biotech's revenue was approximately RMB 516 million, representing a strong growth of 225% from 2021, mainly attributable to the fast sales growth of Boyounuo^® and the successful launch of Boyoubei^® at the end of last year; its gross profit was approximately RMB 354 million, representing an even stronger growth of 233% from 2021, with a gross margin higher than that in 2021.

• Fast progress in R&D: Boyoubei, the first denosumab biosimilar in the world developed by the company, was launched; 1 drug candidate entered the Biological License Application (BLA) stage, 2 saw significant progress with their Phase 3 clinical trials (including BA5101, the world's first dulaglutide biosimilar to enter Phase 3 clinical trials), and 5 innovative antibodies as drug candidates entered Phase 1 clinical trials.

• A new journey in the capital market: Boan Biotech was listed on the Main Board of the Hong Kong Stock Exchange (HKEX) on December 30, 2022, and was included in the Shanghai-Hong Kong Stock Connect and Shenzhen-Hong Kong Stock Connect on March 13, 2023.

Eye-catching performance of two marketed products Boan Biotech's first drug Boyounuo (bevacizumab injection, a biosimilar to Avastin^®) is used for the treatment of multiple cancers. Sales grew rapidly immediately after it was launched in China in May 2021. Its first full-year sales were approximately RMB 515 million in 2022, which was a remarkable performance. Two new indications (ovarian cancer and cervical cancer) were also added for the drug last year, to further expand its patient base. Today, all the five indications of Boyounuo are on the 2022 National Reimbursement Drug List (NRDL). Boyoubei(denosumab injection, a biosimilar to Prolia^®), the company's second product, was launched in China for the treatment of osteoporosis in November 2022. This is the world's first marketed denosumab biosimilar. In addition to China, the company is also developing the product in Europe and the U.S., with a plan to market it globally. Thanks to the strong sales performance of Boyounuo and the company's well-established commercial capabilities, Boyoubeiquickly achieved a number of business milestones in a shorter period of time after its approval. In December 2022, the drug was granted a code for reimbursement by the government's health insurance system. In January 2023, the company granted CP Qingdao, a subsidiary of Sino Biopharm, the exclusive right to commercialize Boyoubei in the Chinese mainland, to put the product on the fast track for commercial success. A fast growing pipeline with multiple first movers Boan Biotech is able to innovate efficiently, and all of its products are in-house developed. The company has three platforms for innovation: the Human Antibody Transgenic Mouse and Phage Display Platform, the Bispecific T-cell Engager Platform, and the Antibody-drug Conjugate (ADC) Platform. On these platforms, Boan Biotech has built a strong portfolio, which includes 2 commercial products, 7 investigational antibodies, and 4 biosimilar candidates. Since 2022, the company has made remarkable progress in the development of multiple investigational drugs. 3 biosimilar candidates to be commercialized: BA1102 (denosumab injection, a biosimilar to Xgeva^®), the BLA of which has been accepted in China, and which is also being developed in Europe and the U.S.; and BA5101 (dulaglutide injection, a biosimilar to Trulicity^®) and BA9101 (aflibercept intravitreous injection, a biosimilar to Eylea^®), both of which are in Phase 3 clinical trials in China, with BA5101 being the world's first dulaglutide biosimilar to enter Phase 3 clinical trials. 5 innovative antibodies under Phase 1 clinical trials: BA1106, a non-IL-2 blocking anti-CD25 antibody, which is the first innovative anti-CD25 antibody for the treatment of solid tumors to enter the clinical trial stage in China; BA2101, an anti-IL-4Rα monoclonal antibody, which is the first long-acting anti-IL-4Rα antibody in the autoimmunity therapeutic area to enter the clinical trial stage in China; BA1105, an ADCC-enhanced anti-Claudin 18.2 antibody, which is expected to become the best-in-class targeted therapy for the treatment of metastatic pancreatic cancer, advanced gastric cancer, and adenocarcinoma of the esophagogastric junction; BA1201, an anti-PD-L1/TGF-β bispecific antibody fusion protein; and BA1301, an injectable ADC targeting Claudin18.2. Boan Biotech keeps a balance between "the value of innovation" and "commercial visibility". While striving to build a differentiated portfolio, it is also speeding up R&D to gain a first-mover advantage. Many of the above-mentioned drug candidates are ahead of competition in terms of development...