HONG KONG SAR - Media OutReach Newswire - 12 September 2025 - With Hong Kong's aging population, Alzheimer's disease has become a major public health challenge. The Hong Kong Council of Social Service projects that by 2036, the number of people with dementia in Hong Kong will reach 280,000. Alzheimer's disease is the most common form of the condition, accounting for approximately 65% of existing cases among elderly individuals. A recent report released by the Dean of the Faculty of Chinese Medicine at a renowned Hong Kong university stated, "Considerable resources have been invested globally in developing treatments for Alzheimer's disease. However, for patients in the middle and late stages of the disease, various treatment options remain ineffective in halting the progression of the disease." These treatments not only have limited effectiveness but also come with side effects, creating an increasingly urgent need for disease prevention and treatment. In 2025, the collaboration between the research team of that leading university in Hong Kong and Prof. Nick Wang, Founder and Head of R&D at eefit has led to a critical breakthrough. They discovered that eefit far infrared technology can simultaneously suppress β-amyloid (Aβ) deposition and tau protein hyperphosphorylation, creating an innovative solution for preventing Alzheimer's disease. The results were published in NeuroMolecular Medicine (Volume 27, Article 34, 2025).First Study with Evidence of Simultaneous Dual-Pathology Improvement Mechanism in Transgenic Mouse Model To address the future need for Alzheimer's disease prevention and treatment in Hong Kong, the research team explored non-pharmacological physical therapies. Using a TgCRND8 transgenic mouse model, they conducted a 28-day irradiation experiment with eefit far infrared light (FIR, wavelength range of 4-20μm) to evaluate its effectiveness in improving disease pathology. The study found:

• Improved cognitive function: The FIR-treated mice group showed significant improvement in cognitive function and memory during the Morris Water Maze Test (MWMT).
• Aβ deposition suppression:Decreased Aβ42/Aβ40 ratio in the cortex, reduced plaque deposits, and increased Aβ clearance.
• Tau protein hyperphosphorylation inhibition: Significantly reduced tau protein phosphorylation levels at different sites, such as Thr205, Ser36, etc., and reduced the formation of neurofibrillary tangles.
• Dual-pathway mechanism: Suppression of neuroinflammatory pathways (reduced IL-1β, TNF-α and increased IL-4) and activation of antioxidant pathways (enhanced Nrf2/HO-1 pathway), achieving dual-pathway protection.

Using a transgenic mouse model, this study confirms for the first time thateefit far infrared technology can simultaneously reduce Aβ deposition and tau protein hyperphosphorylation through physical intervention. Previous studies have only focused on single-pathology interventions, making the significance of this study on the dual-pathway improvement effect groundbreaking.The Dean of the Faculty of Chinese Medicine at a renowned Hong Kong university said, "As a non-invasive treatment option, far infrared therapy has the potential to delay the disease progression of patients with mild cognitive impairment for several years, thereby reducing the burden on overall medical resources and providing significant assistance to families and caregivers." This groundbreaking discovery also provides solid scientific evidence to support the industrial application of eefit far infrared technology. International R&D Team Drives Industrialisation CapabilityTo promote the transformation of far infrared technology from scientific research results to industrial applications, eefit has built aglobal R&D system with scientific research as its core driving force, first collaborating with the "State Key Laboratory of Quality Research in Chinese Medicine" at the Macau University of Science and Technology (M.U.S.T.) to launch the "eefit Biomedical Research Project" in the early years. In 2021, eefit further expanded its global collaboration network by partnering with "Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery", founded by Dr. Erwin Neher, Nobel Prize Laureate in Physiology or Medicine, strengthening its R&D capability. In recent years, multiple international journal articles have confirmed that eefit far infrared technology is effective in the fields of intestinal microecology, rheumatoid arthritis, cerebral stroke, neuroinflammation, and immunomodulation. Market Response and Social Responsibility Are Equally Important In tandem with advancing scientific research, eefit is also dedicated to upholding our social responsibilities. In 2024, eefit launched the "eBrain Movement", which provided brain health services to 212,000 people across our retail stores in Hong Kong. User feedback showed improvement in their bodily conditions, including...